This fluke, distributed widely in Asia, infects the bile duct of mammals including dogs, cats, and humans. The second intermediate hosts are freshwater cyprinidid fish. Humans are infected by eating raw or undercooked freshwater fish. Heavy infection causes ascites, jaundice and anemia, and in serious cases, liver cirrhosis. Human cases have decreased because of the reduction of freshwater snails, the first intermediate host. The fluke has been reported to live in humans for up to 20 years.